ABSTRACT
Se presenta caso de paciente de 13 años, de sexo femenino, con historia de 2 meses de evolución de lesiones aspecto crateriforme en planta de pie izquierdo, acompañado de bromhidrosis, dolor y ardor e impotencia funcional. El cultivo reveló la presencia de Staphylococcus aureus meticilino sensible. Las lesiones mejoraron con tratamiento antibiótico tópico con mupirocina y queratolíticos, quedando como diagnóstico una queratólisis punctata.
A 13-year-old female patient case is presented with a 2 months history of lesions on the left foot, accompanied by bromhydrosis, pain, burning, and functional impotence. Tissue culture revealed the presence of sensitive methicillin Staphylococcus aureus. The lesions improved with topical antibiotic treatment with mupirocin and keratolytics, final diagnosis was punctate keratolysis.
Subject(s)
Humans , Female , Adolescent , Staphylococcal Infections/diagnosis , Staphylococcus aureus/isolation & purification , Keratoderma, Palmoplantar/diagnosis , Keratoderma, Palmoplantar/microbiology , Staphylococcal Infections/drug therapy , Mupirocin/administration & dosage , Keratoderma, Palmoplantar/drug therapy , Keratolytic Agents/therapeutic use , Anti-Bacterial Agents/therapeutic useABSTRACT
HIV/syphilis co-infection is common because both conditions affect similar risk groups. HIV interferes with the natural history of syphilis, which often has atypical clinical features and nervous system involvement in the early stage of disease. We report the case of an HIV-positive patient with secondary syphilis, scaling palmoplantar keratoderma, scrotal eczema, balanitis and urethritis mimicking Reiter’s syndrome. Immunohistochemistry using polyclonal antibodies against Treponema pallidum revealed the presence of spirochetes, associated with the paretic form of parenchymal neurosyphilis. The patient was given crystalline penicillin, with complete resolution of dermatological and neurological symptoms, and no sequelae.
.Subject(s)
Adult , Humans , Male , Arthritis, Reactive/pathology , Coinfection/pathology , HIV Infections/pathology , Neurosyphilis/pathology , Anti-Bacterial Agents/therapeutic use , Biopsy , Diagnosis, Differential , Immunohistochemistry , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Neurosyphilis/drug therapy , Penicillin G/therapeutic use , Treatment OutcomeABSTRACT
Due to diverse clinical and histopathological presentations, diagnosis of secondary syphilis can occasionally prove challenging. Variable clinical presentations of secondary syphilis in HIV disease may result in an incorrect diagnosis and an inappropriate treatment regimen. Similarly, the histology of secondary syphilitic lesions may show considerable variation, depending on the clinical morphology of the eruption. We report a case of secondary syphilis in an HIV infected patient with cutaneous palmoplantar lesions simulating palmoplantar psoriasis.
.Subject(s)
Adult , Humans , Male , HIV Infections/pathology , Psoriasis/pathology , Syphilis, Cutaneous/pathology , Anti-Bacterial Agents/therapeutic use , Biopsy , Coinfection/drug therapy , Coinfection/pathology , Diagnosis, Differential , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/pathology , Penicillin G Benzathine/therapeutic use , Syphilis, Cutaneous/drug therapy , Treatment OutcomeABSTRACT
Presentamos un paciente de 22 años de edad que consulta por queratodermia palmoplantar difusa. A pesar de que las características clínicas son comunes a otras queratodermias, las imágenes histopatológicas nos permiten arribar al diagnóstico de enfermedad de Darier palmoplantar. Nos referimos a un nuevo caso de esta rara entidad y realizamos una revisión de tema.
Subject(s)
Humans , Adult , Female , Darier Disease/diagnosis , Darier Disease/genetics , Darier Disease/drug therapy , Biopsy , Skin/pathology , Keratoderma, Palmoplantar/diagnosis , Keratoderma, Palmoplantar/genetics , Keratoderma, Palmoplantar/drug therapyABSTRACT
Olmsted syndrome is a rare disorder characterized by symmetrical sharply marginated mutilating keratoderma of palms & soles & hyperkeratotic plaques around the body orifices, onychodystrophy, ainhum & amputation of digital phalanges, flextion deformities of the fingers, localized alopecia, leukokeratosis of the tongue, shortness of stature & laxity of large joints. Inheritance is autosomal dominant, although sporadic cases have been reported. Here we describe two cases of this rare disorder with thickened hyperkeratotic lesion over palm & soles & along with amputation of 3rd , 4th & 5th toes in one case. In one of our case (case no. 2) the immediate younger brother has got the same disease. Both of them were treated with tab. Neotegason 25 mg orally daily for 3 months & there was significant improvement after treatment.
Subject(s)
Adolescent , Adult , Congenital Abnormalities , Female , Humans , Joint Instability/pathology , Keratoderma, Palmoplantar/drug therapy , Keratolytic Agents/therapeutic use , Leukoplakia , Male , Skin/pathology , SyndromeABSTRACT
We report the case of a 45 year-old male with palmoplantar hyperkeratosis. He had chronic thyroiditis with severe hypothyroidism. Skin lesions improved upon thyroid hormone replacement. Complete resolution of palmoplantar keratoderma was achieved after 7 months of therapy. The association of acquired palmoplantar keratoderma with hypothyroidism even though extremely unusual, should be considered in the differential diagnosis. It is a reversible condition.
Describimos un paciente de 45 años de sexo masculino, con hiperqueratosis palmoplantar. Simultáneamentese diagnosticó hipotiroidismo primario de origen autoinmune. Al realizar tratamiento sustitutivo con levotiroxina, el cuadro dermatológico se resolvió en el transcurso de siete meses. La queratodermia palmoplantar adquirida asociada a hipotiroidismo es una condición reversible. A pesar de ser una asociación infrecuente, debe ser considerada en el diagnóstico diferencial.
Subject(s)
Humans , Male , Middle Aged , Keratoderma, Palmoplantar/etiology , Hypothyroidism/complications , Keratoderma, Palmoplantar/drug therapy , Hypothyroidism/drug therapy , Thyroxine/therapeutic useABSTRACT
La eritroqueratodermia simétrica progresiva (Gottron) es una dermatosis infrecuente, autosómica dominante. Se caracteriza por placas eritematosas e hipertqueratósicas de aspecto psoriasiforme, simétricas, que afectan extremidades y nalgas, con un carácter fijo muy típico. No afecta la vida de los pacientes, quienes incluso pueden experimentar la regresión espontánea. Presentamos una niña de cinco años con eritroqueratodermia simétrica progresiva a partir de los 20 días de vida. Las lesiones eritematoescamosas afectan cara, miembros, glúteos, axilas, manos y pies. Se asocia distrofia ungueal y descamación del cuero cabelludo. La respuesta al tratamiento con etretinato ha sido inicialmente favorable
Subject(s)
Humans , Female , Child, Preschool , Etretinate/therapeutic use , Keratoderma, Palmoplantar/diagnosis , Darier Disease/complications , Etretinate/administration & dosage , Etretinate/adverse effects , Keratoderma, Palmoplantar/drug therapy , Keratoderma, Palmoplantar/etiology , Retinoids/therapeutic useABSTRACT
Se describe un caso de queratodermia palmoplantar circunscripta, bilateral, con paquioniquia e hiperhidrosis, en una paciente de sexo femenino, de 32 años de edad, sin antecedentes heredofamiliares de la afección. Se la trató con etretinato durante 3 meses , obteniéndose la remisión de las lesiones y su sintomalogía hasta la actualidad. Proponemos, de acuerdo a la revisión realizada, la clasificación de los cuadros de callosidades dolorosas en constitucionales o hereditarias. Nuestro caso constituye la segunda observación en la bibliografía de callosidades dolorosas constitucionales (CDC).